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Teachers' Notes on the Treatment of Embryos
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Aim

For students to know and understand arguments for and against the use of embryos and to consider some of the ethical and moral questions raised by human cloning, reproductive technologies and embryo experimentation.

Issues for Consideration & Discussion

When does life begin?

Crucial question when deciding on the morality of how to treat the human embryo.

 
  • Conception – individual acquires full genetic make-up, everything that determines your physical characteristics, from very first cell division, embryo’s development is directed towards already determined physical appearance.
  • 15 days - spinal column appears and the embryo starts to take on more of a human appearance.
  • Heart starts to beat after 21 days.
  • By day 43 the first brain waves of the embryo can be recorded (O’Rahilly, R, & Muller F, Human Embryology and Teratology, 3rd Ed, New York, John Wiley & Sons Inc., 2001).
  • Around 22 weeks, baby can survive outside the womb with adequate care.
  • Legal personhood is not attributed until birth.
Human Cloning

Reproduction of humans by asexual means to create a genetic copy of an already existing human being.

Why clone? So-called therapeutic cloning – a cloned embryo is created and his/her stem cells are extracted and used for research. The embryo is destroyed in the process.
 

Arguments for – will help us to find cures for genetic conditions by using cloned embryos as a source of stem cells. Using cloned embryos to supply stem cells for the patient who has been cloned will avoid the problem of rejection due to tissue incompatibility often found in bone marrow, organ and other tissue transplants.

Arguments against – to use human beings in this way is morally wrong; human beings are not simply resource material to be exploited. Does not respect the dignity of human beings used in this way. Stem cells can be found from other sources e.g. baby’s placentas and umbilical cords and in many sites within the adult body such as the bone marrow. Adult stem cells are safer than embryonic and cloned embryonic stem cells as their growth is more easily controlled (Dr Lorraine Young of the Roslin Institute, The Daily Telegraph, 1 August 2000).

Reproductive cloning – a cloned embryo is transferred to a woman’s womb in the hope that he/she will implant and develop to birth.

Arguments for – will provide children for those who cannot have children by any other means.

Arguments against – we cannot disregard the moral questions raised by reproductive technologies. Cloning complicates and distorts human relationships – the cloned individual may have only one legal parent who may also be his/her biological sibling since they share genetic parents. The clone might also have a surrogate mother. Raises questions over how cloned human beings would be treated and accepted by society?

Ethical Considerations Is it right to use human beings as a means to an end as in so-called therapeutic cloning – do human beings of all stages of development have an equal right to life and to be treated with dignity and respect?
 

Is it right to destroy embryonic human beings in the name of finding cures for disability? Is it right to use an ethically questionable technique when there is an ethical and moral alternative?

Some people argue that allowing so-called therapeutic cloning will lead to the legalisation of reproductive cloning in the future.

Reproductive cloning of animals has produced serious abnormalities, is it morally acceptable to use such a technique on human beings without any knowledge of the possible outcome? If cloned human embryos created for "therapeutic" purposes are affected in the same way, will they be healthy enough to supply stem cells to those who need them?

What might be the motives behind reproductive cloning and might be the nature of the relationships that it would produce?

In Vitro Fertilisation Asexual reproduction – sperm and eggs are mixed in a dish in order to fertilise the eggs before one or two are transferred to a woman’s womb. Used to help couples with problems conceiving naturally.
Ethical Considerations The Human Fertilisation & Embryology Authority (HFEA) licences IVF clinics and its statistics for the year 2000-2001 show that in 21.8% of treatment cycles a live birth was the result, although rates varied among clinics (HFEA, Press Release August 2002). Therefore in 78.2% of treatment cycles the embryos created did not survive to birth.
 

More embryos are created than are needed. Embryos left-over may be frozen for future use or consent may be given for them to be used in research. Any other “spare” embryos will be discarded. Between 1991 & 1998 750,000 embryos were created by IVF, 237,000 were destroyed and 48,000 were used for research (Yvette Cooper, Public Health Minister; House of Commons, Hansard, 15 December 2000). Treating human beings as “spare” or surplus does not respect the dignity of the individual but instead treats the human embryo as resource material to be used and discarded?

According to the HFEA the success rate using embryos that have been frozen is about 12% (Storage and Use of Frozen Eggs Information for Patients, HFEA, April 2000). Many embryos die as a result of the freezing and thawing process. Embryos who are frozen have their development suspended indefinitely. This process has also raised questions about the health of any children who are born after being frozen as an embryo.

Other techniques such as ICSI (intra-cytoplasmic sperm injection) involve piercing the egg and injecting sperm otherwise too weak to reach and fertilise the egg. Scientists admit that damaging the egg by piercing it and using weak sperm may result in developmental problems for any children created by this technology (Intra-cytoplasmic Sperm Injection, HFEA, June 2002).

IVF is out of control? Black twins born to white parents due to a mix up with the sperm and eggs. Men and women fighting in the courts over frozen embryos.

IVF is a multi-million pound industry, should people be making money from the heartache of those desperate to have children? Are children treated like commodities or property as a result of the development of such technologies? Is it ethical for clinics to offer couples free treatment if they donate their "spare" eggs for use by other couples? The Medical Research Council is also offering fertility clinics money to use their "spare" embryos in research, giving clinics more of an incentive to persuade couples to donate their embryos. Should this be considered ethical?

Pre-Implantation Genetic Diagnosis The testing of embryos to detect genetic conditions or sex-related conditions before implantation.
Ethical Considerations A cell is taken from the newly created embryo in order to screen for disability. When the cells of an embryo split at this stage a twin of the original embryo is created. Once tested the extracted cell is destroyed whereas if left to develop that one cell may develop as a twin of the original embryo. A potential twin is therefore destroyed by these tests.
 

If a genetic disability is found or if the embryo is found to be of the sex that may develop a sex-related disability he/she will be discarded. Many embryos are therefore destroyed in the process of PGD. Of those who pass the test only one or two will be chosen for implantation.

PGD raises questions about how we think about and treat people with disabilities. Can we maintain our respect for people with disabilities if we endorse a technology that prevents people with disabilities from being born?

PGD raises the possibility of ‘designer babies’ as it involves the creation and destruction of embryos based on whether or not they meet a particular specification.

A couple have been given permission to create and test an embryo using PGD to ensure that he/she is both free from a particular disability and is also a tissue match for another child requiring stem cell treatment. Does this respect the right of every individual to be considered valuable for who they are rather than for what they can provide?

The HFEA recently consulted on the possibility of parents being allowed to choose the sex of their children using PGD, simply because they prefer a boy to a girl or vice versa.

Embryo Experimentation The use of embryos of fourteen days and under for research and experimentation. Embryos left-over from IVF treatment are used as well as embryos specially created using donor eggs and sperm.
Why experiment? Arguments for – experiments on embryos will result in the discovery of cures for many disabilities and illnesses. Since embryo research is morally contentious experiments will only be carried out for the prevention and cure of serious genetic and disabling conditions, and not for things such as the common cold or flu.
  Arguments against – Since 1990 between 300,000 and 500,000 embryos have been used for research (The Daily Telegraph, 25 June 1999). The only significant discovery from embryo research into disability is PGD, which does not prevent disability but prevents children with disabilities from being born. However, if there were truly recognition of the moral problem in using human life in this way then embryo experimentation would be banned.
Ethical Considerations Many people with disabilities object to the use and destruction of human embryos in their name. Embryos are destroyed in the process of experimentation. Should we experiment on any human being where they cannot give consent and where they cannot gain any benefit from it themselves and are instead harmed/destroyed?

Questioning the Treatment of Embryos

Scientifically we can establish that once the sperm has fertilised the egg a new human being is created in embryonic form. The scientific community accepts the humanity of the embryo; it is because the embryo is human that it is considered to be so useful for research. Scientists agree that to pinpoint any other stage in our development as the beginning is arbitrary as our development is a continuous process from the point of fertilisation. This was also recognised by the Warnock Committee which made the recommendations on the treatment of embryos that led to the Human Fertilisation and Embryology Act 1990.

The use of any technology that endangers the life of the human embryo disregards the humanity of the embryo and discounts him/her from any right to be treated with dignity and respect? The human embryo is discriminated against on account of his/her stage of development?

Does the use of reproductive technologies establish the idea that everyone has a right to have children? Should people make money out of the heartache of those who are childless?

Does reproductive technology, including PGD, change how we treat and value children in our society, considering we now see men and women fighting in court over frozen embryos? Are children now seen as commodities or property in our society?

Does PGD establish the idea that not only does everyone have the right to have children, but also that everyone has the right to a ‘perfect’ child? Does PGD influence how society views and treats people with disabilities?

Does our society treat children as important for what they can provide rather than as important for who they are when we produce siblings by PGD to provide the necessary genetic material to treat their ill brother/sister? Is this also true for embryos used in experimentation and cloned embryos used in stem cell research, that they are seen as a means to someone else’s ends and are seen as resource material rather than as human beings?


SPUC Scotland
Revised June 2004
Jacqueline Dalrymple

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